Scientific References

At Nextrient, we base our products off the cutting edge of nutritional science. When creating new products, we scour the research in order to validate our product ideas. In this way, we bring the best products and ingredients directly to you.

Below is an interactive list of current Nextrient products with references.

Araújo, Lidiane Advincula de, Flavia Addor, and Patrícia Maria Berardo Gonçalves Maia Campos. “Use of Silicon for Skin and Hair Care: An Approach of Chemical Forms Available and Efficacy.” Anais Brasileiros de Dermatologia 91, no. 3 (June 2016): 331–35. https://doi.org/10.1590/abd1806-4841.20163986.
Barel, A., M. Calomme, A. Timchenko, K. De. Paepe, N. Demeester, V. Rogiers, P. Clarys, and D. Vanden Berghe. “Effect of Oral Intake of Choline-Stabilized Orthosilicic Acid on Skin, Nails and Hair in Women with Photodamaged Skin.” Archives of Dermatological Research 297, no. 4 (October 2005): 147–53. https://doi.org/10.1007/s00403-005-0584-6.
Calomme, M., P. Geusens, N. Demeester, G. J. Behets, P. D’Haese, J. B. Sindambiwe, V. Van Hoof, and D. Vanden Berghe. “Partial Prevention of Long-Term Femoral Bone Loss in Aged Ovariectomized Rats Supplemented with Choline-Stabilized Orthosilicic Acid.” Calcified Tissue International 78, no. 4 (April 2006): 227–32. https://doi.org/10.1007/s00223-005-0288-0.
Calomme, Mario R., and Dirk A. Vanden Berghe. “Supplementation of Calves with Stabilized Orthosilicic Acid: Effect on the Si, Ca, Mg, and P Concentrations in Serum and the Collagen Concentration in Skin and Cartilage.” Biological Trace Element Research 56, no. 2 (February 1997): 153–65. https://doi.org/10.1007/BF02785389.
Dong, Meng, Guangjun Jiao, Haichun Liu, Wenliang Wu, Shangzhi Li, Qingshi Wang, Daxia Xu, Xiaofeng Li, Huan Liu, and Yunzhen Chen. “Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway.” Biological Trace Element Research 173, no. 2 (October 2016): 306–15. https://doi.org/10.1007/s12011-016-0686-3.
Exley, Christopher. “Silicon in Life : A Bioinorganic Solution to Bioorganic Essentiality.” J. Inorg. Biochem., 1998, 6.
Geusens, Piet, Karel Pavelka, Jozef Rovensky, Johan Vanhoof, Nathalie Demeester, Mario Calomme, and Dirk Vanden Berghe. “A 12-Week Randomized, Double-Blind, Placebo-Controlled Multicenter Study of Choline-Stabilized Orthosilicic Acid in Patients with Symptomatic Knee Osteoarthritis.” BMC Musculoskeletal Disorders 18, no. 1 (December 2017). https://doi.org/10.1186/s12891-016-1370-7.
Jugdaohsingh, Ravin, Simon HC Anderson, Katherine L Tucker, Hazel Elliott, Douglas P Kiel, Richard PH Thompson, and Jonathan J Powell. “Dietary Silicon Intake and Absorption.” The American Journal of Clinical Nutrition 75, no. 5 (May 1, 2002): 887–93. https://doi.org/10.1093/ajcn/75.5.887.
Jugdaohsingh, Ravin, Supannee Sripanyakorn, and Jonathan J. Powell. “Silicon Absorption and Excretion Is Independent of Age and Sex in Adults.” British Journal of Nutrition 110, no. 06 (September 2013): 1024–30. https://doi.org/10.1017/S0007114513000184.
Jurkić, Lela Munjas, Ivica Cepanec, Sandra Kraljević Pavelić, and Krešimir Pavelić. “Biological and Therapeutic Effects of Ortho-Silicic Acid and Some Ortho-Silicic Acid-Releasing Compounds: New Perspectives for Therapy.” Nutrition & Metabolism 10, no. 1 (2013): 2. https://doi.org/10.1186/1743-7075-10-2.
Nakanishi, Luciana, Bruna Bombonatti, Letícia Sabo Muller, Ricardo Tadeu Villa, Maria Valéria Robles Velasco, and Valcinir Bedin. “Oral Supplementation of Orthosilicic Acid and Its Impact on Hair Quality,” n.d., 7.
Pruksa, Supannee, Atitaya Siripinyanond, Jonathan J Powell, and Ravin Jugdaohsingh. “Silicon Balance in Human Volunteers; a Pilot Study to Establish the Variance in Silicon Excretion versus Intake.” Nutrition & Metabolism 11, no. 1 (2014): 4. https://doi.org/10.1186/1743-7075-11-4.
Reffitt, D.M, N Ogston, R Jugdaohsingh, H.F.J Cheung, B.A.J Evans, R.P.H Thompson, J.J Powell, and G.N Hampson. “Orthosilicic Acid Stimulates Collagen Type 1 Synthesis and Osteoblastic Differentiation in Human Osteoblast-like Cells in Vitro.” Bone 32, no. 2 (February 2003): 127–35. https://doi.org/10.1016/S8756-3282(02)00950-X.
Seaborn, C D, and F H Nielsen. “Silicon Deprivation Decreases Collagen Formation in Wounds and Bone, and Ornithine Transaminase Enzyme Activity in Liver.” Biological Trace Element Research 89, no. 3 (2002): 251–62. https://doi.org/10.1385/BTER:89:3:251.
Spector, Tim D, Mario R Calomme, Simon H Anderson, Gail Clement, Liisa Bevan, Nathalie Demeester, Rami Swaminathan, Ravin Jugdaohsingh, Dirk A Vanden Berghe, and Jonathan J Powell. “Choline-Stabilized Orthosilicic Acid Supplementation as an Adjunct to Calcium/Vitamin D3 Stimulates Markers of Bone Formation in Osteopenic Females: A Randomized, Placebo-Controlled Trial.” BMC Musculoskeletal Disorders 9, no. 1 (December 2008). https://doi.org/10.1186/1471-2474-9-85.
Sripanyakorn, Supannee, Ravin Jugdaohsingh, Wacharee Dissayabutr, Simon H. C. Anderson, Richard P. H. Thompson, and Jonathan J. Powell. “The Comparative Absorption of Silicon from Different Foods and Food Supplements.” British Journal of Nutrition 102, no. 06 (September 2009): 825. https://doi.org/10.1017/S0007114509311757.
Wickett, R. R., E. Kossmann, A. Barel, N. Demeester, P. Clarys, D. Vanden Berghe, and M. Calomme. “Effect of Oral Intake of Choline-Stabilized Orthosilicic Acid on Hair Tensile Strength and Morphology in Women with Fine Hair.” Archives of Dermatological Research 299, no. 10 (November 15, 2007): 499–505. https://doi.org/10.1007/s00403-007-0796-z.
Zhou, Xianfeng, Fouad M. Moussa, Steven Mankoci, Putu Ustriyana, Nianli Zhang, Samir Abdelmagid, Jim Molenda, William L. Murphy, Fayez F. Safadi, and Nita Sahai. “Orthosilicic Acid, Si(OH) 4 , Stimulates Osteoblast Differentiation in Vitro by Upregulating MiR-146a to Antagonize NF-ΚB Activation.” Acta Biomaterialia 39 (July 2016): 192–202. https://doi.org/10.1016/j.actbio.2016.05.007.